ABSTRACT
To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1[st], 2010 and May 1[st], 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department The information including age, sex, weight, diagnosis, size of affected area, site of extravasation and treatment was collected. The extravasation injuries alleviated and the symptoms improved after treatment, no adverse drug effects were reported with use of hyaluronidase and hirudoid. The treatment appeared to be beneficial in the management of extravasations of various medications in neonates and may be useful in reducing the severity of cutaneous toxicosis. However, further studies with large samples are still needed to assess the effectiveness and safety of hyaluronidase and hirudoid
ABSTRACT
Objective: To investigate the effect of aerosolized pulmonary surfactant (PS) on the blood oxygenation in rats with acute lung injury(ALI). Methods: Forty-three SD rats were randomly divided into 4 groups: sham group (operated only, n = 10), model group(n=10), air-NS group (inhaling aerosolized normal saline, n=10), and air-PS group (inhaling aerosolized PS[160 mg], n=13). ALI rats were induced by oleic acid(0.2 ml/kg) through jugular vein. The arterial blood gas and breathing rates were determined during the experiment in all groups. The survival rates of all groups were determined after experiments. Results: PS aerosolization led to a gradual increase of PaO2 and SaO2. Four hours after inhalation of aerosolized PS, the PaO 2 and SaO2 increased to 99.4 mmHg(1 mmHg=0.133 kPa) and 98.2%, respectively, which were significantly higher than those in the air-NS group (P< 0.05). The breathing rate began to decease 0.5 h after inhalation of aerosolized PS and decreased to 100 breaths/min 4 h later, which was significantly lower than that in the air-NS group at the same time point (P<0.05). The survival rate of animals in the air-PS group was 100%, also significantly higher than that in the air-NS group (60% , P<0.05). Conclusion: Aerosolized PS through spontaneous breathing can improve the blood oxygenation, pulmonary function and survival rates of ALI rats.